Neuronal spike-rate adaptation supports working memory in language processing.

ABSTRACT: Language processing involves the ability to store and integrate pieces of information in working memory over short periods of time. According to the dominant view, information is maintained through sustained, elevated neural activity. Other work has argued that short-term synaptic facilitation can serve as a substrate of memory. Here we propose an account where memory is supported by intrinsic plasticity that downregulates neuronal firing rates. Single neuron responses are dependent on experience, and we show through simulations that these adaptive changes in excitability provide memory on timescales ranging from milliseconds to seconds. On this account, spiking activity writes information into coupled dynamic variables that control adaptation and move at slower timescales than the membran

SUBMITTER: Fitz H 

PROVIDER: S-EPMC7456144 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature