Repeatability of Quantitative ¹⁸F-DCFPyL PET/CT Measurements in Metastatic Prostate Cancer.

ABSTRACT: Quantitative evaluation of radiolabeled prostate-specific membrane antigen (PSMA) PET scans may be used to monitor treatment response in patients with prostate cancer (PCa). To interpret longitudinal differences in PSMA uptake, the intrinsic variability of tracer uptake in PCa lesions needs to be defined. The aim of this study was to investigate the repeatability of quantitative PET/CT measurements using ¹⁸F-DCFPyL ([2-(3-(1-carboxy-5-[(6-¹⁸F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid], a second-generation ¹⁸F-PSMA-ligand) in patients with PCa. Methods: Twelve patients with metastatic PCa were prospectively included, of whom 2 were excluded from final analyses. Patients received 2 whole-body ¹⁸F-DCFPyL PET/CT scan

SUBMITTER: Jansen BHE 

PROVIDER: S-EPMC7456167 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature