Integrated microbiota and metabolite profiles link Crohn's disease to sulfur metabolism.

ABSTRACT: Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome and metabolite analysis of a longitudinal cohort of Crohn's disease patients undergoing autologous hematopoietic stem cell transplantation, and investigational therapy that induces drug free remission in a subset of patients. Via comparison of patients who responded and maintained remission, responded but experienced disease relapse and patients who did not respond to therapy, we identify shared functional signatures that correlate with disease activity despite the variability of gut microbiota profiles at taxonomic level. These signatures reflect the disease state when transferred to gnotobiotic mice. Taken together, the integration of micr

SUBMITTER: Metwaly A 

PROVIDER: S-EPMC7456324 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature