Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.

ABSTRACT: We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

SUBMITTER: Oldenburg CE 

PROVIDER: S-EPMC7456340 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature