Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.

ABSTRACT:

Background

Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide who are currently infected with human T-cell leukemia virus type 1. Recurrent somatic mutations in host genes have exposed the T-cell receptor pathway through nuclear factor κB to interferon regulatory factor 4 (IRF4) as an essential driver for this malignancy. We sought to determine if IRF4 represents a therapeutic target for ATLL and to identify downstream effectors and biomarkers of IRF4 signaling in vivo.

Results

ATLL cell lines, particularly Tax viral oncoprotein-negative cell lines, that most closely resemble ATLL in humans, were sensitive to dose- and ti

SUBMITTER: Rauch DA 

PROVIDER: S-EPMC7456374 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature