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Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases.


ABSTRACT: Recent research progress on the "second generation" type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R1-C-R2 scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent opportunities for the manipulation of the enzyme reactions to expand the supply of natural and unnatural molecules for future drug development.

SUBMITTER: Abe I 

PROVIDER: S-EPMC7456412 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases.

Abe Ikuro I  

Journal of natural medicines 20200605 4


Recent research progress on the "second generation" type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R<sub>1</sub>-C-R<sub>2</sub> scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent op  ...[more]

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