On the nature of thiamine triphosphate in Arabidopsis.

ABSTRACT: Vitamin B₁ is a family of molecules, the most renowned member of which is diphosphorylated thiamine (TDP)-a coenzyme vital for the activity of key enzymes of energy metabolism. Triphosphorylated thiamine derivatives also exist within this family, specifically thiamine triphosphate (TTP) and adenosine thiamine triphosphate (ATTP). They have been investigated primarily in mammalian cells and are thought to act as metabolic messengers but have not received much attention in plants. In this study, we set out to examine for the presence of these triphosphorylated thiamine derivatives in Arabidopsis. We could find TTP in Arabidopsis under standard growth conditions, but we could not detect ATTP. Interestingly, TTP is found primarily in shoot tissue. Drivers of TTP synthesis are light

SUBMITTER: Hofmann M 

PROVIDER: S-EPMC7456500 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature