Association analysis between chronic obstructive pulmonary disease and polymorphisms in circadian genes.

ABSTRACT:

Background

Circadian genes have been suggested to play an important role in lung pathology. However, it remains unknown whether polymorphisms of these genes are associated with chronic obstructive pulmonary disease (COPD). Here, we aimed to investigate the association of circadian genes polymorphisms with COPD in a case-control study of 477 COPD patient and 323 control Han Chinese persons.

Methods

Genotyping assays were carried out for nine single nucleotide polymorphisms (SNPs) from five circadian genes (PER3, CLOCK, RORB, BMAL1 and CRY2) that were previously identified in lung pathology. Age, sex, BMI and smoking status and comorbidities were recorded for all subjects.

Results

No significant association was found in all SNP sites i

SUBMITTER: Chen G 

PROVIDER: S-EPMC7456532 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature