Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes.

ABSTRACT:

Objective

High-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence spermatogenesis and sperm motility.

Design

Faecal microbes derived from the HFD-fed or normal diet (ND)-fed male mice were transplanted to the mice maintained on ND. The gut microbes, sperm count and motility were analysed. Human faecal/semen/blood samples were collected to assess microbiota, sperm quality and endotoxin.

Results

Transplantation of the HFD gut microbes into the ND-maintained (HFD-FMT) mice resulted in a significant decrease in spermatogenesis and sperm motility, whereas similar transplantation with the microbes from the ND-fed mice failed to do so. Analysis of the micro

SUBMITTER: Ding N 

PROVIDER: S-EPMC7456731 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature