Fine-Tuning of Energy Levels Regulates SUC2 via a SNF1-Dependent Feedback Loop.

ABSTRACT: Nutrient sensing pathways are playing an important role in cellular response to different energy levels. In budding yeast, Saccharomyces cerevisiae, the sucrose non-fermenting protein kinase complex SNF1 is a master regulator of energy homeostasis. It is affected by multiple inputs, among which energy levels is the most prominent. Cells which are exposed to a switch in carbon source availability display a change in the gene expression machinery. It has been shown that the magnitude of the change varies from cell to cell. In a glucose rich environment Snf1/Mig1 pathway represses the expression of its downstream target, such as SUC2. However, upon glucose depletion SNF1 is activated which leads to an increase in SUC2 expression. Our single cell experiments indicate that

SUBMITTER: Persson S 

PROVIDER: S-EPMC7456839 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature