Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People.

ABSTRACT:

Objective

To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 10³) over time among cognitively normal older people.

Methods

We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal cognition (NC) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. At baseline, a total of 372 individuals with NC were included.

Results

In the cross-sectional analyses of baseline data, we did not find a significant relationship between OA and HpVR among individuals with NC. However, in the longitudinal analyses, OA was significantly associated with change in HpVR over time among individuals with NC. Specifically, compared wit

SUBMITTER: Li X 

PROVIDER: S-EPMC7456859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature