Tristetraprolin Regulates T_H17 Cell Function and Ameliorates DSS-Induced Colitis in Mice.

ABSTRACT: T_H17 cells have been extensively investigated in inflammation, autoimmune diseases, and cancer. The precise molecular mechanisms for T_H17 cell regulation, however, remain elusive, especially regulation at the post-transcriptional level. Tristetraprolin (TTP) is an RNA-binding protein important for degradation of the mRNAs encoding several proinflammatory cytokines. With newly generated T cell-specific TTP conditional knockout mice (CD4^CreTTP^f/f), we found that aging CD4^CreTTP^f/f mice displayed an increase of IL-17A in serum and spontaneously developed chronic skin inflammation along with increased effector T_H17 cells in the affected skin. TTP inhibited T_H17 cell development and function by promoting IL-

SUBMITTER: Peng H 

PROVIDER: S-EPMC7457025 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature