Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.

ABSTRACT:

Background

Prostate cancer (PCa) is one of the most common malignant tumors worldwide. Accumulating evidence has suggested that circular RNAs (circRNAs) are involved in the development and progression of various cancers, and they show great potential as novel biomarkers. However, the underlying mechanisms and specific functions of most circRNAs in PCa remain unknown. Here, we aimed to identify circRNAs with potential roles in PCa from the PCa expression profile.

Methods

We used data downloaded from the Gene Expression Omnibus to identify circRNAs that were differentially expressed between PCa samples and adjacent non-tumor samples. Relative expression levels of identified circRNAs were validated by quantitative real-time PCR. Micro (mi)RNA response elements were predicted by

SUBMITTER: Wu YP 

PROVIDER: S-EPMC7457069 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature