Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H.

ABSTRACT: Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases. Complement factors are mainly liver-born and present in circulation. Nevertheless, there is a growing body of evidence for additional sites of complement protein synthesis, including various cell types in the kidney. We hypothesized that podocytes are able to produce complement components and contribute to the local balance of complement activation and regulation. To investigate the relevant balance between inhibiting and activating sides, our studies focused on complement factor H (CFH), an important complement regulator, and on C3, the early key component for complement activation. We characterized huma

SUBMITTER: Muhlig AK 

PROVIDER: S-EPMC7457071 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature