Dataset Information

ANDC: an early warning score to predict mortality risk for patients with Coronavirus Disease 2019.

ABSTRACT:

Background

Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients with COVID-19.

Methods

301 patients with confirmed COVID-19 admitted to Main District and Tumor Center of the Union Hospital of Huazhong University of Science and Technology (Wuhan, China) between January 1, 2020 to February 15, 2020 were enrolled in this retrospective two-centers study. Data on patient demographic characteristics, laboratory findings and clinical outcomes was analyzed. A nomogram was constructed to predict the death probability of COVID-19 patients.

Results

Age, neutrophil-to-lymphocyte ratio, D-dimer and C-reactive protein obtained on admission were identified as predictors of mortality for COVID-19 patients by LASSO. The nomogram demonstrated good calibration and discrimination with the area under the curve (AUC) of 0.921 and 0.975 for the derivation and validation cohort, respectively. An integrated score (named ANDC) with its corresponding death probability was derived. Using ANDC cut-off values of 59 and 101, COVID-19 patients were classified into three subgroups. The death probability of low risk group (ANDC < 59) was less than 5%, moderate risk group (59 ≤ ANDC ≤ 101) was 5% to 50%, and high risk group (ANDC > 101) was more than 50%, respectively.

Conclusion

The prognostic nomogram exhibited good discrimination power in early identification of COVID-19 patients with high mortality risk, and ANDC score may help physicians to optimize patient stratification management.

SUBMITTER: Weng Z

PROVIDER: S-EPMC7457219 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Publications

ANDC: an early warning score to predict mortality risk for patients with Coronavirus Disease 2019.

Weng Zhihong Z Chen Qiaosen Q Li Sumeng S Li Huadong H Zhang Qian Q Lu Sihong S Wu Li L Xiong Leiqun L Mi Bobin B Liu Di D Lu Mengji M Yang Dongliang D Jiang Hongbo H Zheng Shaoping S Zheng Xin X

Journal of translational medicine 20200831 1

<h4>Background</h4>Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients with COVID-19.<h4>Methods</h4>301 patients with confirmed COVID-19 admitted to Main District and Tumor Center of the Union Hospital of Huazhong University of Science and Technology (Wuhan, China) between January 1, 2020 to February 15, 2020 were enrolled in this retrospectiv ...[more]

PMID: 32867787

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Dataset Information

ANDC: an early warning score to predict mortality risk for patients with Coronavirus Disease 2019.

Background

Methods

Results

Conclusion

Publications

ANDC: an early warning score to predict mortality risk for patients with Coronavirus Disease 2019.

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