Identification of hepatocellular carcinoma prognostic markers based on 10-immune gene signature.

ABSTRACT:

Background

Due to the heterogeneity of hepatocellular carcinoma (HCC), hepatocelluarin-associated differentially expressed genes were analyzed by bioinformatics methods to screen the molecular markers for HCC prognosis and potential molecular targets for immunotherapy.

Methods

RNA-seq data and clinical follow-up data of HCC were downloaded from The Cancer Genome Atlas (TCGA) database. Multivariate Cox analysis and Lasso regression were used to identify robust immunity-related genes. Finally, a risk prognosis model of immune gene pairs was established and verified by clinical features, test set and Gene Expression Omnibus (GEO) external validation set.

Results

A total of 536 immune-related gene (IRGs) were significantly associated with the prognosis of patients with HC

SUBMITTER: Zhao K 

PROVIDER: S-EPMC7457228 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature