The fusiform gyrus exhibits an epigenetic signature for Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common type of dementia, and patients with advanced AD frequently lose the ability to identify family members. The fusiform gyrus (FUS) of the brain is critical in facial recognition. However, AD etiology in the FUS of AD patients is poorly understood. New analytical strategies are needed to reveal the genetic and epigenetic basis of AD in FUS.

Results

A complex of new analytical paradigms that integrates an array of transcriptomes and methylomes of normal controls, AD patients, and "AD-in-dish" models were used to identify genetic and epigenetic signatures of AD in FUS. Here we identified changes in gene expression that are specific to the FUS in brains of AD patients. These changes are closely linked to key genes in the AD ne

SUBMITTER: Ma D 

PROVIDER: S-EPMC7457273 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature