Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development.

ABSTRACT:

Background

Chlamydia trachomatis and Chlamydia muridarum are intracellular bacterial pathogens of mucosal epithelial cells. CD4 T cells and major histocompatibility complex (MHC) class II molecules are essential for protective immunity against them. Antigens presented by dendritic cells (DCs) expand naive pathogen-specific T cells (inductive phase), whereas antigens presented by epithelial cells identify infected epithelial cells as targets during the effector phase. We previously showed that DCs infected by C trachomatis or C muridarum present epitopes from a limited spectrum of chlamydial proteins recognized by Chlamydia-specific CD4 T cells from immune mice.

Methods

We hypothesized that Chlamydia-infected DCs and epithelial cells present overlapping sets of Chlamydia-MHC

SUBMITTER: Karunakaran KP 

PROVIDER: S-EPMC7457330 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature