The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles.

ABSTRACT: A novel bioactive inorganic material containing silicon, calcium and oxygen, calcium silicate (Ca₂SiO₄, C₂S) with a CaO-SiO₂ ingredient, has been identified as a potential candidate for artificial bone. Autophagy has an essential function in adult tissue homoeostasis and tumorigenesis. However, little is known about whether silicate nanoparticles (C₂S NPs) promote osteoblastic differentiation by inducing autophagy. Here we investigated the effects of C₂S NPs on bone marrow mesenchymal stem cell differentiation (BMSCs) in osteoblasts. Furthermore, we identified the osteogenic gene and protein expression in BMSCs treated with C₂S NPs. We found that autophagy is important for the ability of C₂S NPs to indu

SUBMITTER: Ruolan W 

PROVIDER: S-EPMC7457372 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature