Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium.

ABSTRACT: Most high-grade serous carcinomas are thought to arise from Fallopian tube epithelium (FTE), but some likely arise outside of the tube, perhaps from ectopic tubal-type epithelium known as endosalpingiosis. Importantly, the origin of endosalpingiosis is poorly understood. The proximity of the tubal fimbriae to the ovaries has led to the proposal that disruptions in the ovarian surface that occur during ovulation may allow detached FTE to implant in the ovary and form tubal-type glands and cysts. An alternative model suggests that cells present in ectopic locations outside the Müllerian tract retain the capacity for multi-lineage differentiation and can form glands with tubal-type epithelium. We used double transgenic Ovgp1-iCreER^T2 ;R26R^LSL-eYFP mice, which express an

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7457448 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature