Group penalized generalized estimating equation for correlated event-related potentials and biomarker selection.

ABSTRACT:

Background

Event-related potentials (ERP) data are widely used in brain studies that measure brain responses to specific stimuli using electroencephalogram (EEG) with multiple electrodes. Previous ERP data analyses haven't accounted for the structured correlation among observations in ERP data from multiple electrodes, and therefore ignored the electrode-specific information and variation among the electrodes on the scalp. Our objective was to evaluate the impact of early adversity on brain connectivity by identifying risk factors and early-stage biomarkers associated with the ERP responses while properly accounting for structured correlation.

Methods

In this study, we extend a penalized generalized estimating equation (PGEE) method to accommodate structured correlation of E

SUBMITTER: Lin Y 

PROVIDER: S-EPMC7457526 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature