Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism.

ABSTRACT:

Background

In primary aldosteronism (PA), kidney function impairment could be concealed by relative hyperfiltration and emerge after adrenalectomy. We hypothesized transtubular gradient potassium gradient (TTKG), a kidney aldosterone bioactivity indicator, could correlate to end organ damage and forecast kidney function impairment after adrenalectomy.

Methods

In the present prospective study, we enrolled lateralized PA patients who underwent adrenalectomy and were followed up 12 months after operation in the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry from 2010 to 2018. The clinical outcome was kidney function impairment, defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m² at 12 months after adrenalectomy. End organ damage is

SUBMITTER: Liao HW 

PROVIDER: S-EPMC7457632 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature