Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement.

ABSTRACT:

Background

As vitamins and dietary supplements are obtainable without prescription, treating physicians often ignore their intake by patients with multiple sclerosis (MS) and may therefore miss potential adverse effects and interactions.

Objective

We aimed to assess the spectrum and intake frequency of supplementary medication in a cohort of MS patients and to analyse the effect of biotin intake on measurement of serum neurofilament light chain (sNfL), an emerging marker of disease activity.

Methods

MS patients visiting our neurology outpatient clinic completed a questionnaire on their past or present use of vitamins or dietary supplements. In addition, the impact of two different doses of biotin (10 and 300 mg/day) on sNfL was studied in healthy volunteers.

Result

SUBMITTER: Pape K 

PROVIDER: S-EPMC7457677 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature