GCNT4 is Associated with Prognosis and Suppress Cell Proliferation in Gastric Cancer.

ABSTRACT:

Background

GCNT4 is a member of the glucosaminyl (N-acetyl) transferases family that has been implicated in multiple human malignancies. However, the role of GCNT4 in gastric cancer (GC) is unknown. In this present study, we aimed to explore the role and clinicopathological correlation of GCNT4 in GC.

Materials and methods

We first evaluated the dysregulation of GCNT4 in The Cancer Genome Atlas (TCGA) and then we performed RT-qPCR and immunohistochemistry to validate the results in a cohort of in-house patients. The clinicopathological correlation and function of GCNT4 in GC were also analysed.

Results

GCNT4 was found to be significantly downregulated in GC. In addition, GCNT4 expression correlated with tumour depth, nervous invasion and pathological tumor-node-metast

SUBMITTER: Sun H 

PROVIDER: S-EPMC7457769 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature