Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes.

ABSTRACT:

Background

Endocrine cells of the zebrafish digestive system play an important role in regulating metabolism and include pancreatic endocrine cells (PECs) clustered in the islets of Langerhans and the enteroendocrine cells (EECs) scattered in the intestinal epithelium. Despite EECs and PECs are being located in distinct organs, their differentiation involves shared molecular mechanisms and transcription factors. However, their degree of relatedness remains unexplored. In this study, we investigated comprehensively the similarity of EECs and PECs by defining their transcriptomic landscape and comparing the regulatory programmes controlled by Pax6b, a key player in both EEC and PEC differentiations.

Results

RNA sequencing was performed on EECs and PECs isolated from wild-type

SUBMITTER: Lavergne A 

PROVIDER: S-EPMC7457809 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature