¹⁸F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L.

ABSTRACT:

Purpose

F-FDOPA is a highly sensitive and specific radiopharmaceutical for pheochromocytoma and paraganglioma (PPGL) imaging. However, ¹⁸F-FDOPA might be falsely negative in these tumors, especially those related to mutations in succinate dehydrogenase genes (SDHx). The aim of the present study was to evaluate the relationship between expression of L-DOPA transporters and ¹⁸F-FDOPA PET imaging results in PPGL.

Methods

From 2007 to 2015, 175 patients with non-metastatic PPGL were evaluated by ¹⁸F-FDOPA PET/CT for initial diagnosis/staging and follow-up. ¹⁸F-FDOPA PET/CT was considered as falsely negative for at least one lesion in 10/126 (8%) patients (two sporadic, six SDHD, two SDHB PPGLs). The mRNA and protein expression levels o

SUBMITTER: Feral CC 

PROVIDER: S-EPMC7457903 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature