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ABSTRACT: Objectives
To assess the methodologies used in the estimation of diagnostic accuracy of SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and other nucleic acid amplification tests (NAATs) and to evaluate the quality and reliability of the studies employing those methods.Methods
We conducted a systematic search of English-language articles published December 31, 2019-June 19, 2020. Studies of any design that performed tests on ≥10 patients and reported or inferred correlative statistics were included. Studies were evaluated using elements of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) guidelines.Results
We conducted a narrative and tabular synthesis of studies organized by their reference standard strategy or compara
SUBMITTER: Axell-House DB
PROVIDER: S-EPMC7457918 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature