Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes.

ABSTRACT:

Context

In healthy individuals, glucose-dependent insulinotropic polypeptide (GIP) enhances insulin secretion and reduces bone resorption by up to 25% estimated by absolute placebo-corrected changes in carboxy-terminal type 1 collagen crosslinks (CTX) during GIP and glucose administration. In patients with type 2 diabetes (T2D), GIP's insulinotropic effect is impaired and effects on bone may be reduced.

Objective

To investigate GIP's effect on bone biomarkers in patients with T2D.

Design

Randomized, double-blinded, crossover study investigating 6 interventions.

Patients

Twelve male patients with T2D.

Interventions

A primed continuous 90-minute GIP infusion (2 pmol/kg/min) or matching placebo (saline) administered at 3 plasma glucose (PG) levels (i.e., pa

SUBMITTER: Christensen MB 

PROVIDER: S-EPMC7458112 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature