Lymphocyte infiltration and key differentially expressed genes in the ulcerative colitis.

ABSTRACT:

Background

Ulcerative colitis (UC) was a type of inflammatory bowel diseases, which was difficult to cure and even would malignant turn into colon cancer. The specific etiology and molecular mechanism of UC were unclear to date. The purpose of this study was to search for new targets for the diagnosis and treatment of UC.

Methods

Firstly, we downloaded the gene expression data of UC from the gene expression omnibus database database (GSE107499), and used multiple bioinformatics methods to find differently expressed genes (DEGs) in UC. Subsequently, we evaluated the lymphocyte infiltration in UC inflamed colon tissue by using the cell type identification by estimating relative subset of known RNA transcripts method.

Results

We obtained 1175 DEGs and 8 hub genes (IL6, T

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7458201 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature