Injectables' key role in rifampicin-resistant tuberculosis shorter treatment regimen outcomes.

ABSTRACT:

Background

Since a meta-analysis showed little or no effect of second-line injectables on treatment success, and using injectables may induce ototoxicity, injectable-free rifampicin-resistant tuberculosis (RR-TB) treatment regimens are recommended. However, acquired resistance preventing activity was overlooked. No previous study assessed the effect of shortening the duration of kanamycin administration to 2 months during the intensive phase of the RR-TB shorter treatment regimen (STR).

Methods

Retrospective cohort study of the effect of using 2 months of kanamycin instead of the standard 4(+) months (extension if lack of smear conversion at 4 months) on recurrence (either treatment failure or relapse) and fluoroquinolone acquired drug resistance, in patients treated with a

SUBMITTER: Decroo T 

PROVIDER: S-EPMC7458281 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature