Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy.

ABSTRACT:

Background

Perinatally HIV-infected children on anti-retroviral treatment (ART) are reported to have metabolic abnormalities such as dyslipidemia, lipodystrophy, and insulin resistance which potentially increase the risk of diabetes, kidney, liver and cardiovascular disease.

Objective

To elucidate HIV-mediated metabolic complications that sustain even during ART in perinatally HIV-infected children.

Method

We have carried out metabolic profiling of the plasma of treatment-naïve and ART-suppressed perinatally HIV-infected children and uninfected controls using 1H nuclear magnetic resonance (NMR) spectroscopy followed by statistical analysis and annotation.

Result

Validated multivariate analysis showed clear distinction among our study groups. Our results showed

SUBMITTER: Kaur S U 

PROVIDER: S-EPMC7458310 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature