Ontology highlight
ABSTRACT: Background
Stringent complete response (sCR) is used as a deeper response category than complete response (CR) in multiple myeloma (MM) but may be of limited value in the era of minimal residual disease (MRD) testing.Methods
Here, we used 4-colour multiparametric flow cytometry (MFC) or next-generation sequencing (NGS) of immunoglobulin genes to analyse and compare the prognostic impact of sCR and MRD monitoring. We included 193 treated patients in two institutions achieving CR, for which both bone marrow aspirates and biopsies were available.Results
We found that neither the serum free light chain ratio, clonality by immunohistochemistry (IHC) nor plasma cell bone marrow infiltration identified CR patients at distinct risk. Patients with sCR had slightly longer progression-free survival. Nevertheless, persistent clonal bone marrow disease was detectable using MFC or NGS and was associated with significantly inferior outcomes compared with MRD-negative cases.Conclusion
Our results confirm that sCR does not predict a different outcome and indicate that more sensitive techniques are able to identify patients with differing prognoses. We suggest that MRD categories should be implemented over sCR for the future classification of MM responses.
SUBMITTER: Cedena MT
PROVIDER: S-EPMC7458342 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cedena Maria-Teresa MT Martin-Clavero Estela E Wong Sandy S Shah Nina N Bahri Natasha N Alonso Rafael R Barcenas Carmen C Valeri Antonio A Salazar Tabares Johny J Sanchez-Pina Jose J Cuellar Clara C Martin Thomas T Wolf Jeffrey J Lahuerta Juan-Jose JJ Martinez-Lopez Joaquin J
PloS one 20200831 8
<h4>Background</h4>Stringent complete response (sCR) is used as a deeper response category than complete response (CR) in multiple myeloma (MM) but may be of limited value in the era of minimal residual disease (MRD) testing.<h4>Methods</h4>Here, we used 4-colour multiparametric flow cytometry (MFC) or next-generation sequencing (NGS) of immunoglobulin genes to analyse and compare the prognostic impact of sCR and MRD monitoring. We included 193 treated patients in two institutions achieving CR, ...[more]