Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury.

ABSTRACT:

Background & aims

Chronic outcome following acute idiosyncratic drug-induced liver injury (DILI) is not yet defined. This prospective, long-term follow-up study aimed to analyze time to liver enzyme resolutions to establish the best definition and risk factors of DILI chronicity.

Methods

298 out of 850 patients in the Spanish DILI registry with no pre-existing disease affecting the liver and follow-up to resolution or ⩾1year were analyzed. Chronicity was defined as abnormal liver biochemistry, imaging test or histology one year after DILI recognition.

Results

Out of 298 patients enrolled 273 (92%) resolved ⩽1year from DILI recognition and 25 patients (8%) were chronic. Independent risk factors for chronicity were older age [OR: 1.06, p=0.011], dyslipidemia [OR: 4.26,

SUBMITTER: Medina-Caliz I 

PROVIDER: S-EPMC7458366 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature