Experimental assessment of permethrin-fipronil combination in preventing Leishmania infantum transmission to dogs under natural exposures.

ABSTRACT: Canine vector-borne disease transmission can be reduced with regular use of repellent insecticides. The objective of this year-long experimental study was to assess the efficacy of a topical formulation of fipronil/permethrin (Frontline Tri-Act®) in preventing transmission of Leishmania infantum by sandflies. This clinical field trial was conducted in Xanthi (Northern Greece), an area highly endemic for canine leishmaniosis, from April 2018 to March 2019. Forty purpose-bred Beagle dogs, testing negative for L. infantum prior to study initiation, were enrolled in the study, which consisted of three phases: Phase 1 (field exposure phase) took place from Day 0-196. The dogs were randomly allocated to two groups, group 1 (sham-treated topically with sterile water) and group 2 (tr

SUBMITTER: Papadopoulos E 

PROVIDER: S-EPMC7458379 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature