Chain reactions: molecular mechanisms of RBR ubiquitin ligases.

ABSTRACT: Ubiquitination is a fundamental post-translational modification that regulates almost all aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases. The RING-between-RING (RBR) family of E3 ligases encompasses 14 distinct human enzymes that are defined by a unique domain organisation and catalytic mechanism. Detailed characterisation of several RBR ligase family members in the last decade has revealed common structural and mechanistic features. At the same time these studies have highlighted critical differences with respect to autoinhibition, activation and catalysis. Importantly, the majority of RBR E3 ligases remain poorly studied, and thus the extent of diversity within the family remains unknown. In this mini-review we outline the current underst

SUBMITTER: Cotton TR 

PROVIDER: S-EPMC7458406 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature