Identification of human CD4⁺ T cell populations with distinct antitumor activity.

ABSTRACT: How naturally arising human CD4⁺ T helper subsets affect cancer immunotherapy is unclear. We reported that human CD4⁺CD26^high T cells elicit potent immunity against solid tumors. As CD26^high T cells are often categorized as T_H17 cells for their IL-17 production and high CD26 expression, we posited these populations would have similar molecular properties. Here, we reveal that CD26^high T cells are epigenetically and transcriptionally distinct from T_H17 cells. Of clinical importance, CD26^high and T_H17 cells engineered with a chimeric antigen receptor (CAR) regressed large human tumors to a greater extent than enriched T_H1 or T_H2 cells. Only human CD26^high T cell

SUBMITTER: Nelson MH 

PROVIDER: S-EPMC7458458 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature