IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8⁺ T-cell responses.

ABSTRACT: Antitumor immunity is mediated by Th1 CD4⁺ and CD8⁺ T lymphocytes, which induce tumor-specific cytolysis, whereas Th17 CD4⁺ T cells have been described to promote tumor growth. Here, we explored the influence of IL-17 on the ability of therapeutic vaccines to induce the rejection of tumors in mice using several adjuvants known to elicit either Th1 or Th17-type immunity. Immunization of mice with Th1-adjuvanted vaccine induced high levels of IFN-γ-producing T cells, whereas injection with Th17-promoting adjuvants triggered the stimulation of both IL-17 and IFN-γ-producing T cells. However, despite their capacity to induce strong Th1 responses, these Th17-promoting adjuvants failed to induce the eradication of tumors. In addition, the systemic administration

SUBMITTER: Dadaglio G 

PROVIDER: S-EPMC7458594 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature