Genomic and immunologic correlates of LAG-3 expression in cancer.
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ABSTRACT:
SUBMITTER: Panda A
PROVIDER: S-EPMC7458666 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Genomic and immunologic correlates of LAG-3 expression in cancer.
Panda Anshuman A Rosenfeld Jeffrey A JA Singer Eric A EA Bhanot Gyan G Ganesan Shridar S
Oncoimmunology 20200522 1
Immune checkpoint blockade leads to unprecedented responses in many cancers. Although currently available agents mostly target the PD-1 and CTLA-4 pathways, agents targeting the immune checkpoint protein LAG-3 are under active clinical development, and early clinical data show that <i>LAG-3</i> expression is a biomarker of response to LAG-3 blockade. To determine which cancers may benefit most from LAG-3 blockade, we performed a pan-cancer analysis of The Cancer Genome Atlas dataset to identify ...[more]
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