Modelling the linkage between influenza infection and cardiovascular events via thrombosis.

ABSTRACT: There is a heavy burden associated with influenza including all-cause hospitalization as well as severe cardiovascular and cardiorespiratory events. Influenza associated cardiac events have been linked to multiple biological pathways in a human host. To study the contribution of influenza virus infection to cardiovascular thrombotic events, we develop a dynamic model which incorporates some key elements of the host immune response, inflammatory response, and blood coagulation. We formulate these biological systems and integrate them into a cohesive modelling framework to show how blood clotting may be connected to influenza virus infection. With blood clot formation inside an artery resulting from influenza virus infection as the primary outcome of this integrated model, we demonstrate how

SUBMITTER: McCarthy Z 

PROVIDER: S-EPMC7458909 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature