PI3K-Akt pathway mediated antiviral mechanism in silkworm Antheraea mylitta.

ABSTRACT: Bombyx mori nucleopolyhedrosis virus (BmNPV) is a highly pathogenic virus to domestic silkworm Bombyx mori, often causing severe economic losses to silk industry. Interestingly, there are no documented reports of NPV infection in the wild silkworm Antheraea mylitta. Analysis of gene expression datasets and comparative genomic analysis of sequence datasets from B. mori and A. mylitta was undertaken to unravel the potential immune-related proteins and immune pathways involved. The B. mori silkworm races Sarupat and CSR-2 which are resistant and susceptible to BmNPV respectively were selected and challenged with virus to study BmNPV resistance related genes and their expression profile. The genes were filtered to isolate membrane proteins, their seque

SUBMITTER: Nallabothula T 

PROVIDER: S-EPMC7459008 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature