Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients.

ABSTRACT: This study compared the tumor immune microenvironments (TIMEs) of primary gastric cancer (PGC) and paired metastatic gastric cancer (MGC). CD4⁺ and CD8⁺ T-cell density and PD-L1 expression were evaluated by multiplex immunohistochemistry, DNA mismatch repair (MMR) by immunohistochemistry, and immune-related genes by RNA sequencing. Twenty-three patients who underwent surgical treatment for PGC and MGC were enrolled in this study. CD8⁺ T-cell, PD-L1⁺ cell, and PD-L1⁺CK⁺ cell densities were significantly lower in MGC than PGC. PD-L1 positivity using a combined positive score (≥ 1%) and deficient MMR were observed in 52.2% and 8.7% of PGC samples, respectively, whereas both occurred in only 4.3% of MGC samples. The most frequen

SUBMITTER: Son SM 

PROVIDER: S-EPMC7459099 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature