ABHD4-dependent developmental anoikis safeguards the embryonic brain.

ABSTRACT: A specialized neurogenic niche along the ventricles accumulates millions of progenitor cells in the developing brain. After mitosis, fate-committed daughter cells delaminate from this germinative zone. Considering the high number of cell divisions and delaminations taking place during embryonic development, brain malformations caused by ectopic proliferation of misplaced progenitor cells are relatively rare. Here, we report that a process we term developmental anoikis distinguishes the pathological detachment of progenitor cells from the normal delamination of daughter neuroblasts in the developing mouse neocortex. We identify the endocannabinoid-metabolizing enzyme abhydrolase domain containing 4 (ABHD4) as an essential mediator for the elimination of pathologically detached cells. Conseq

SUBMITTER: Laszlo ZI 

PROVIDER: S-EPMC7459116 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature