Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis.

ABSTRACT: The therapeutic effects of low intensity pulsed ultrasound (LIPUS) on renal ischemia/reperfusion injury (IRI) with acute kidney injury (AKI) are still unclear. A renal tubule cell model under H₂O₂ or hypoxia/reoxygenation (H/R) conditions with or without LIPUS pre-treatment (1 MHz, 30 and 100 mW/cm², 15 min) was used to test the in vitro effects of LIPUS. An AKI mouse model of unilateral IRI with nephrectomy of the contralateral kidney for 48 h with or without LIPUS treatment (3 MHz, 100 mW/cm², 20 min/day) 5 day before IRI were used to investigate the in vivo effects of LIPUS. LIPUS significantly protected the renal tubule cell viability and prevented inflammatory signals against H₂O₂ challenge. LIPUS could inhibit the apop

SUBMITTER: Chiang CK 

PROVIDER: S-EPMC7459306 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature