Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction.

ABSTRACT: Learned fear and safety are associated with distinct oscillatory states in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC). To determine if and how these network states support the retrieval of competing memories, we mimicked endogenous oscillatory activity through optogenetic stimulation of parvalbumin-expressing interneurons in mice during retrieval of contextual fear and extinction memories. We found that exogenously induced 4 Hz and 8 Hz oscillatory activity in the BLA exerts bi-directional control over conditioned freezing behavior in an experience- and context-specific manner, and that these oscillations have an experience-dependent ability to recruit distinct functional neuronal ensembles. At the network level we demonstrate, via simultaneous manipulation of BLA a

SUBMITTER: Ozawa M 

PROVIDER: S-EPMC7459312 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature