Tolerance to alkaline ambient pH in Aspergillus nidulans depends on the activity of ENA proteins.

ABSTRACT: Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans. While EnaC has a minor role, EnaB is a key element for tolerance to Na⁺ and Li⁺ toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na⁺, Li⁺ and pH 8. These expression patterns are altered in a sltAΔ background and completely inhibited in a muta

SUBMITTER: Markina-Inarrairaegui A 

PROVIDER: S-EPMC7459330 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature