The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study.

ABSTRACT:

Background

Primary aldosteronism is a nonsuppressible renin-independent aldosterone production that causes hypertension and cardiovascular disease.

Objective

To characterize the prevalence of nonsuppressible renin-independent aldosterone production, as well as biochemically overt primary aldosteronism, in relation to blood pressure.

Design

Cross-sectional study.

Setting

4 U.S. academic medical centers.

Participants

Participants with normotension (n = 289), stage 1 hypertension (n = 115), stage 2 hypertension (n = 203), and resistant hypertension (n = 408).

Measurements

Participants completed an oral sodium suppression test, regardless of aldosterone or renin levels, as a confirmatory diagnostic for primary aldosteronism

SUBMITTER: Brown JM 

PROVIDER: S-EPMC7459427 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature