Dimerization of Dengue Virus E Subunits Impacts Antibody Function and Domain Focus.

ABSTRACT: Dengue virus (DENV) is responsible for the most prevalent and significant arthropod-borne viral infection of humans. The leading DENV vaccines are based on tetravalent live-attenuated virus platforms. In practice, it has been challenging to induce balanced and effective responses to each of the four DENV serotypes because of differences in the replication efficiency and immunogenicity of individual vaccine components. Unlike live vaccines, tetravalent DENV envelope (E) protein subunit vaccines are likely to stimulate balanced immune responses, because immunogenicity is replication independent. However, E protein subunit vaccines have historically performed poorly, in part because the antigens utilized were mainly monomers that did not display quaternary-structure epitopes found on E dimers

SUBMITTER: Thomas A 

PROVIDER: S-EPMC7459570 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature