Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor.

ABSTRACT: The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradi

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7459580 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature