Organoarsenic Compounds with In Vitro Activity against the Malaria Parasite Plasmodium falciparum.

ABSTRACT: The rapid development of parasite drug resistance as well as the lack of medications targeting both the asexual and the sexual blood stages of the malaria parasite necessitate the search for novel antimalarial compounds. Eleven organoarsenic compounds were synthesized and tested for their effect on the asexual blood stages and sexual transmission stages of the malaria parasite Plasmodium falciparum using in vitro assays. The inhibitory potential of the compounds on blood stage viability was tested on the chloroquine (CQ)-sensitive 3D7 and the CQ-resistant Dd2 strain using the Malstat assay. The most effective compounds were subsequently investigated for their effect on impairing gametocyte development and gametogenesis, using the gametocyte-producing NF54 strain in respective cell-based as

SUBMITTER: Basova S 

PROVIDER: S-EPMC7459655 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature