Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429.

ABSTRACT: The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC_50</

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7460381 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature